Applications Of EPR Spectroscopy In Pharma And Structural Biology Workflows

Understanding protein structure often requires insight into dynamic interactions and conformational changes that conventional methods struggle to capture. Electron paramagnetic resonance (EPR) spectroscopy provides precise distance constraints and distributions that can reveal protein flexibility, complex formation, and structural arrangements. Explore four applications across pharmaceutical and structural biology workflows, including investigating ligand-induced changes in GPCRs, characterizing protein-protein complexes involved in targeted protein degradation, measuring the dynamics of intrinsically disordered proteins, and supporting structural validation for Cryo-EM and AlphaFold models.

Access the full infographic for a concise look at where EPR can add clarity to challenging structural biology questions.