Application Of ExD Viewer For The Structural Characterization Of Impurities Generated During Peptide Process Development

Solid phase peptide synthesis generates impurities through chemistry rather than biology, which makes structural characterization closer to cheminformatics than bioinformatics. Add proprietary sequences and non-natural residues, and software that accommodates them has been hard to find. A scientist from a peptide CDMO's Boulder, Colorado site describes how cycle-specific MS/MS method development, collision energy selection, and impurity identification work in practice, using a GLP-1 example and a custom synthesized peptide built to avoid proprietary data.

Take a look at what automation does to development timelines and where regulatory expectations may push next.