Analysis Of Partial Capsids Using The Vericheck ddPCR™ Empty-Full Capsid Kit

Gene therapy relies on well-packaged AAV vectors, but some particles can be mispackaged, lacking complete genetic material. This application note demonstrates how to extend the Vericheck ddPCR Empty-Full Capsid Kit to provide a comprehensive assessment of AAV genome integrity. By replacing the included ITR-2 assay with alternative HEX assays targeting other genes, researchers can compare fill rates across multiple genomic regions, revealing the presence of partial capsids.

This offers increased workflow flexibility and deeper insights into packaging efficiency. Download the full app note to learn more about expanding your AAV analysis capabilities.