Amsphere® A+ Affinity Chromatography Resin – Stability And Resin Life Cycle

Resin lifetime sits at the center of Protein A capture economics, because it determines how much resin a process needs and what it costs to run. This application note tests a Protein A resin built around an engineered, caustic-tolerant ligand under harsh cleaning conditions. Binding capacity retention after 24 hour sodium hydroxide soaks is compared across an established platform resin and two other market-leading resins. A separate life cycle study follows a clarified mAb harvest through repeated capture and cleaning-in-place cycles, tracking capacity, recovery, host cell protein levels, and leached Protein A. One resin was run for twice as many cycles as the others, and the results show where the differences emerge.

Explore the data to see how the resins compare.