Alzheimer's Disease Pathway

Alzheimer’s disease (AD) is the most prevalent form of dementia, affecting an estimated 50 million people globally. Despite its widespread impact, the precise causes and underlying mechanisms of AD symptoms—characterized by a progressive decline in cognitive function due to the loss of neurons and synapses—remain largely unknown. AD is classified as a proteopathy, a disease associated with protein misfolding. The most widely accepted hypothesis suggests that the symptoms of AD are triggered by the accumulation and aggregation of amyloid beta (Aβ) proteins in the brain. This buildup is believed to disrupt the cytoskeleton, leading to neuronal cell death.

Our Alzheimer's disease poster delves into the intricate signaling pathways leading to the buildup of amyloid beta and tau proteins and examines their connection to cytoskeleton degradation, cellular demise, and the manifestation of disease symptoms.