AgentSCREEN™ GMP Adventitious Virus Detection By NGS

A GMP‑qualified Next Generation Sequencing (NGS) workflow provides an advanced approach to adventitious virus detection, offering unbiased identification of both expected and unexpected viral contaminants in a single assay. The method delivers broad coverage, high sensitivity, and shorter turnaround times compared to traditional virology testing, supporting modern viral safety strategies that seek to reduce reliance on animal‑based methods.

The process evaluates all messenger RNA present in cell bank samples to detect active infections from both RNA and DNA viruses. Validated software ensures audit trails, data integrity, and compliance with regulatory expectations, while a curated viral reference database enables accurate contaminant identification.

Lifecycle flexibility allows application from early cell banks through late‑stage production testing, and the rich dataset it generates supports retrospective investigations when unexpected viral signals appear. This NGS approach strengthens safety assurance and aligns with evolving global guidance encouraging modernized viral detection methods.