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Advances In Single-Use Technologies For Cell Clarification

Source: Sartorius Stedim Biotech

By Hemanth Kaligotla

Advances In Single-Use Technologies For Cell Clarification

One of the major challenges in batch mammalian cell clarification is cost-effective improvement in filtration in the face of high cell densities. Single-use technology has serious benefits for flexibility in production, pilot or clinical batches, but with existing filtration equipment, the economic benefits have not been fully realized at volumes < 2,000 liters. Developers and CMOs alike require cell clarification technology that offers higher yields, fewer failures, and the ease of use of single-use, with reduced consumables costs for cost-effective drug development and production.