White Paper

Adoption Of Single-Use For Final Filtration

By Terri Love and Youness Cherradi

pharmamanufacturer450x300

Single-use systems (SUS) are now used routinely in the manufacture of biologics in both upstream and downstream operations. The biopharmaceutical industry has seen increased use of these technologies over the past decade and this trend continues with a global market expected to grow to over $4.3 billion by 2021.

A recent development is the adoption of single-use assemblies for final filtration. These assemblies have evolved from the first simple assemblies of a capsule with tubing to more complex designs, which enable pre-use integrity testing, blow-down and sampling. Among others, GSK (Barnard Castle, U.K.) and Roche Diagnostics GmbH (Mannheim, Germany) successfully implemented single-use assemblies in their final fill process steps.

At GSK, the main driver for moving from stainless steel to SUS was the need to rapidly meet the intense demands of influenza vaccine production.  SUS offered flexibility, robustness, and speed of implementation, and while cost reduction was not the primary concern, SUS were operationally efficient by minimizing the clean-in-place and sterilization needs associated with a multiuse product facility. Implementation of  SUS at GSK reduced the campaign fill time from 36 to 12 hours, which led to a 40% improvement in capacity, allowing GSK to manufacture more batches and meet future demand for vaccines.

VIEW THE WHITE PAPER!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of BioProcess Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: