Adeona Pharmaceuticals And National Neurovision Research Institute (NNRI) Collaborate To Test Flupirtine For Retinitis Pigmentosa
National Neurovision Research Institute (NNRI), a research support organization for the Foundation Fighting Blindness, the leading non-government funding source for inherited orphan retinal degeneration research and Adeona Pharmaceuticals, Inc. announced recently a research collaboration whereby NNRI will fully fund preclinical studies to evaluate the potential of flupirtine for the treatment of retinitis pigmentosa (RP), a blinding eye disease that currently lacks an FDA approved treatment.
Retinitis pigmentosa (RP) refers to a group of inherited diseases causing retinal degeneration. The condition affects approximately 100,000 patients in the US. In normal eye function, retina cells lining the inside back wall of the eye are responsible for capturing images from the visual field. RP causes the eye's photoreceptor cells (rods and cones) to die, leading to a gradual decline in vision that ultimately results in blindness. There is no cure or effective therapy for RP.
Adeona and NNRI will test flupirtine in several established animal models with RP at the NNRI Preclinical Assessment Center at the Bascom Palmer Eye Institute, University of Miami. Should these studies provide positive results, Adeona and the NNRI will explore proceeding to clinical trials using flupirtine in RP. During 2008, Adeona obtained an option to license issued and pending patents covering flupirtine's use for the treatment of ophthalmic disorders, such as RP, glaucoma and AMD. Through clinical experience in Europe, approximately 27 RP patients have taken flupirtine for up to 5 years.
"Flupirtine offers a potential new approach to effectively treat people affected by retinitis pigmentosa," said Steve Rose, Ph.D., Chief Research Officer, Foundation Fighting Blindness. "RP is among the most difficult to treat and represents a significant unmet medical need. Flupirtine has the potential to change the lives of patients affected by this devastating condition that is a major cause of vision loss."
Nicholas Stergis, Adeona's chief executive officer, commented, "We are pleased to have entered into this agreement with the NNRI, and we are grateful for the National Neurovision Research Institute/Foundation Fighting Blindness' support for this program."
About Flupirtine
Oral flupirtine has been approved as a treatment of pain in Europe since 1984 but has never been approved for any indication in the US. Flupirtine, a non-opiate analgesic, has been used in Europe for post-surgical pain, cancer pain, trauma pain, pain associated with liver disease, and other nocioceptive pain states. According to post-marketing surveillance, flupirtine has been given to more than 1.5 million patients and 2,776 patients have been studied in various controlled clinical trials with flupirtine.
About National Neurovision Research Institute (NNRI)
NNRI is a recently-established non-profit support organization of the Foundation Fighting Blindness (FFB), the leading non-government funding source for inherited orphan retinal degeneration research. The mission of the NNRI is to accelerate the translation of laboratory based research into clinical trials for treatments and cures of retinal degenerative diseases. It is a medical research institute that will obtain support from government agencies, corporations and private foundations. It may also receive royalties or licensing fees from the drug discovery processes and commercialization of new therapies. For further information about the NNRI, please visit: http://www.nnri.info
The FFB is a non-profit health foundation that has been incorporated since 1971. Over the years FFB has invested over $140M to provide seed money for scientific research of diseases of the retina causing blindness. To learn more, visit: www.FightBlindness.org.
About Adeona Pharmaceuticals, Inc.
Adeona Pharmaceuticals, Inc. is a specialty pharmaceutical company that is developing proprietary, late-stage drug candidates for the treatment of autoimmune and central nervous system diseases. Adeona's strategy is to exclusively in-license proprietary, clinical-stage drug candidates and to complete the further clinical testing, manufacturing, regulatory requirements and seek marketing authorizations. Adeona is focused on treating rheumatoid arthritis, dry age-related macular degeneration (AMD), multiple sclerosis (MS), and fibromyalgia. For further information, please visit: www.adeonapharma.com.
SOURCE: Adeona Pharmaceuticals, Inc.