Accelerating CAR And TCR Discovery With Single-Cell Functional Screening

The identification of high-affinity chimeric antigen receptors (CARs) and T-cell receptors (TCRs) is a critical step in the development of novel adoptive cell therapies. However, traditional screening methods can be time-consuming and labor-intensive. The Beacon platform offers a revolutionary approach to single-cell functional screening, enabling rapid and efficient identification of promising candidates.

By directly assessing the functional properties of individual cells, the Beacon platform eliminates the need for intermediate steps, such as clonal expansion or flow cytometry. This streamlined workflow significantly accelerates the target discovery process, allowing researchers to rapidly identify and characterize CAR and TCR candidates with desired functionalities.

In this application note, we examine how the Beacon platform can be used to screen TCR, CAR, or peptide libraries for functional activity. Through a series of case studies, learn about the successful application of Beacon technology in discovering novel CAR and TCR candidates for adoptive cell therapy.