A Single-Use Bioreactor For Both Cell And Microbial Cultures: A Dream Becomes Reality
By Nico M.G. Oosterhuis, Frank H. van Dongen, CELLution Biotech BV
Application of single-use equipment is common practice in the biopharmaceutical industrial and academic field. Compared to the traditional glass or stainless steel bioreactors, single-use bioreactors offer clear advantages: a quicker turnaround time; minimal utilities required; greatly reduced risk of cross contamination; more operational flexibility; reduced validation requirements. However, until recently, single-use bioreactors could only be used for animal cell cultures, due to limitations in mixing and mass-transfer.
As single-use technology not only has significant benefits for cell culture processes, but clearly also for microbial fermentation processes and for seed-trains, process development and small scale production, there is a strong need for singleuse bioreactors supporting more demanding bioprocesses.
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