A Novel Platform For icIEF Fractionation Of Antibody Charge Variants
While imaged capillary isoelectric focusing electrophoresis (imaged cIEF or icIEF) has become the method of choice for monitoring charge variant levels of biotherapeutics, the in-depth characterization of charge variants has been carried out mostly by mass spectrometry (MS).
The MauriceFlexTM system is a new and innovative Maurice platform featuring icIEF-based fractionation for collecting protein charge variants, enabling downstream analysis of these variants with techniques such as MS. The fractionation utilizes a special cartridge to perform isoelectric focusing to separate protein charge variants, and once focused and separated, the charge variants are eluted via chemical mobilization for fraction collection.
Learn more about MauriceFlex, it's fractionation workflow, and the results it produces.
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