Process Resin Selection Guide: A Journey Through The Protein Purification Workflow

Bio-Rad offers numerous chromatography products for the purification and characterization of biomolecules such as proteins, peptides, and nucleic acids. A resin manufacturer for over 50 years, Bio-Rad has expertise in investigating and manipulating pore structure, bead rigidity, mass transfer rate, ligand structures, and ligand density. These parameters are adjusted so that our chromatography beads provide optimal performance in the purification of biopharmaceuticals. Such characteristics are modulated for the production of both analytical grade and process-scale resins. Process-scale resins provide excellent flow rates when packed in columns of diameters up to 2 m and stability over many CIP cycles. The selectivity provided by the process-scale resins is also useful for laboratory separations with the best resolution often provided by the smaller bead/analytical grade resin.