Application Note

A Guide To Adherent Scale-Up


The market for innovative new treatments is becoming increasingly competitive as decades of experiments are coming to fruition in an ongoing biomedical revolution. Treatments that could target rare human conditions are being produced and challenging biomanufacturers ability to scale-up and meet demand. To maximize efficiency and reduce time to market, they need to plan how to scale-up adherent cell culture early in the research and development process, and effectively manage the factors that will allow for success along the way.

The Corning® CellCube® System offers the benefits of bioreactor control with the familiarity of 2D cell culture. The Corning Ascent® FBR System provides something close to a 3D growth environment for adherent cell cultures with the convenience of a purpose-built bioreactor. Finally, polystyrene or dissolvable microcarriers provide maximum flexibility but require significantly more process development time. Explore how to utilize these manufacturing-ready platform solutions for upstream adherent cell culture for a wide range of applications.

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