A Generic Biomass Soft Sensor And Its Application In Bioprocess Development

Biomass concentration is a key process variable, which is used to identify trends and initiate process events in microbial bioprocesses. Real-time data on the biomass is essential to implement advanced control strategies, including the control of biomass-specific nutrient uptake rates. This group has developed a biomass soft sensor based on readily available measurements and process parameters. They used the soft sensor to control various substrate uptake rates in parallel small-scale bioreactors.