Newsletter | May 23, 2025

05.23.25 -- 8 Ways To Drive Resilience In Oncology Drug Supply Chains

NEW PODCAST EPISODE

Leading A tRNA Startup With Alltrna's Michelle Werner

On the Business of Biotech, Alltrna CEO Michelle Werner discusses how engineered tRNA therapies could treat thousands of rare genetic diseases. She shares how her child's diagnosis influenced her drug development approach, explores Alltrna’s use of AI and machine learning, and outlines plans for basket trials. Hosted by Ben Comer with guest co-host Anna Rose Welch. Brought to you by Avantor.

FOCUS ON SUPPLY CHAIN

8 Ways To Drive Resilience In Oncology Drug Supply Chains

From traditional chemotherapy to advanced immunotherapies and nanotechnology, pharma/biotech companies must overcome logistical hurdles that affect their oncology products' availability and quality.

Deep Interpretation Of GMP Product Quality

Explore the critical aspects of GMP-grade raw materials in CGT manufacturing, including contamination control, aseptic strategies, quality systems, supply chain security, and regulatory compliance.

What You Need To Know About Fluoropolymer Bag Cold Chain Durability

Drug manufacturers seek packaging that maintains integrity during processing and freezing, scales up to larger volumes easily, and remains robust throughout the temperature-controlled supply chain.

Friendshoring: A Strategic Shift In Pharma Supply Chains

To safeguard the consistent delivery of essential therapies to patients around the world, biopharmaceutical companies, alongside their CDMO partners, are rethinking traditional supply models.

Integration Of Container Closure Integrity In Contract Manufacturing

Maintaining drug product sterility and compliance demands rigorous Container Closure Integrity (CCI) within contract manufacturing. Learn how to fortify your processes.

SUPPLY CHAIN SOLUTIONS

GORE STA-PURE Flexible Freeze Container User Guidelines - W.L. Gore & Associates

Solutions For Cell & Gene Therapy Manufacturing - Avantor

FOCUS ON PROCESS ENGINEERING

ADCs Unleashed: Navigating Development Hurdles In Targeted Therapies

Despite their potential to revolutionize treatment paradigms, antibody-drug conjugates (ADCs) face challenges that companies must tackle for successful development.

The 3 Most Overlooked Costs In Monoclonal Antibody Production

Review the dynamic field of therapeutic biotechnology, the intricacies of mAb manufacturing, and the often-overlooked factors driving high production costs.

Close Is Not Close Enough: Micropositioners' Role In Nanopositioning

This article examines how micropositioners affect movement and positioning capability, as well as overall task effectiveness, by creating — literally — a solid foundation for work at the nanoscale.

The Power Couple: CRISPR And Oligonucleotides

Drug design using CRISPR depends on long guide RNA (gRNA) sequences. Find out how this match between long oligos and CRISPR works.

Particle Investigation: Going One Step Further Than Just The Identification

Uncover examples of visible particle identification and the root cause investigation, along with a discussion of the performance of additional troubleshooting using advanced and innovative technologies.

De-Mystifying Regulatory Support During Viral Vector-Based Development

Navigating trials for viral vector-based C&G therapies demands specialized expertise and regulatory insight. Learn how scientific acumen and strategic planning bring therapies from lab to patient.

Expression, in vivo Maturation And Tag-Less Purification

Optimizing recombinant expression and scalable purification strategies can help accelerate the production of challenging proteins, enabling successful program initiation and advancing pipelines.

Phobic Vs. Philic: Indicating The Membrane In Bioprocess Applications

Some membranes attract water ("hydrophilic"), while others repel it ("hydrophobic"). Here, we take a look at which is best for your application.

Navigating Challenges In Process Development, Characterization

Delve into the key obstacles encountered in biologics process development, including the complexities of optimizing production processes, ensuring product consistency, and maintaining quality control.

Rapid Delivery Of Toxicological Study Material: Accelerating Development

Address analytical considerations and material flows that better facilitate the rapid delivery of toxicological material with these key strategies and technologies.

ThioBridge Conjugates

Enable the next generation of stable, scalable, and clinically advanced ADCs through site-specific conjugation with Abzena’s ThioBridge technology.

PROCESS ENGINEERING SOLUTIONS

Efficient Process Lifecycle Management For Optimized Drug Development And Tech Transfer - IDBS UK HQ

The ExPERT VLx System - Superior Transfection Scalability And Efficiency - MaxCyte, Inc.

GS Discovery Transient Expression System - Lonza

Potency Assay Development — Creating Potential Together - Labcorp Biopharmaceutical CMC Services

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