Newsletter | April 9, 2025

04.09.25 -- 3 Strategies For mAb Manufacturing: How Do You Choose?

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Webinar: Sterile Gas Filtration and Optimization in Bioprocessing

This webinar will explore the role of sterilizing-grade gas/vent filters in bioprocessing, highlighting their function as sterile barriers using hydrophobic membranes. Join Entegris as they address challenges like premature fouling and key factors affecting performance, such as flow rate, membrane type, and system design. Their experts will discuss optimizing filter selection to enhance efficiency, cost-effectiveness, and scalability in critical bioprocessing applications. Click here to learn more.

FOCUS ON DOWNSTREAM MANUFACTURING

3 Strategies For mAb Manufacturing: How Do You Choose?

As cost and supply come under more scrutiny, there are primarily three scaling strategies for mAb manufacturing that can be leveraged, each with its own set of pros and cons.

Five Advantages Of Dual-Sourcing In Pharmaceutical Fill/Finish

Delve into the specific advantages of dual-sourcing in pharmaceutical fill/finish, exploring how this approach can bolster supply chain resilience, increase capacity, and accelerate commercialization.

New To mRNA Manufacturing? Considerations For Starting

Examine considerations for starting mRNA manufacturing related to the following topics: DNA template, mRNA product - IVT, mRNA product - purification, LNP encapsulation, and fill-finish.

Scaling Analysis Of Protein Capture Devices

Explore the scalability of a capture device through dynamic binding capacity, CHO cell harvest, and purification experiments as demonstrated with a partially purified monoclonal antibody.

A Cost-Effective Alternative To Traditional Protein A Resin Chromatography

Get to know this cost-effective, efficient alternative to traditional Protein A resin chromatography for mAb production, capable of enhancing productivity and reducing costs.

Compressed Gas Systems In Aseptic Manufacturing

Learn about compressed gas systems and why effectively identifying and managing the risks associated with these systems is critical for maintaining product quality and ensuring compliance with GMP.

Strategies For Endotoxin Removal In Therapeutic Protein Purification

Endotoxins can cause major upheaval in downstream purification. Explore case studies using various resins that have been successfully used for endotoxin removal.

DOWNSTREAM MANUFACTURING SOLUTIONS

Praesto AP+80 Chromatography Resin - Ecolab, Purolite Resins

Advanced Tubing Retainers: Pharma+ - Nordson MEDICAL

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The debate rages on. While the automation that enables continuous processing gets a lot of hype, there are plenty of dyed-in-the-wool biopharma pros who contend that process optimization and intensification yield comparable benefits, without requiring the capital-intensive process overhaul that continuous demands. Join Bioprocess Online Live for a virtual deep dive into the scalability, sustainability, and capital implications of the continuous-versus-optimized debate. Registration is free thanks to the support of Cytiva.

FOCUS ON FILL-FINISH

Challenges Associated With In-Use Simulated Administration Of Biologics

Explore some of the more challenging aspects surrounding in-use testing for parenteral delivery along with potential strategies to address these issues.

FILL-FINISH SOLUTIONS

PharmaLok ZerO Sanitary Clamps - Nordson MEDICAL

Prefilled Syringe Plungers - West Pharmaceutical Services, Inc.

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