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UPSTREAM PROCESSING FEATURED ARTICLES

How Can You Mitigate The Risks Of Single-Use Bags?
How Can You Mitigate The Risks Of Single-Use Bags?

The loss of product as a result of bag failure isn’t just an annoyance; it’s an expense, and a costly one at that. However, Chuck Hart, director of manufacturing at Prolong Pharmaceuticals, says with proper fitting and handling, these concerns can be mitigated.

  • Genomics & Tissue Phenomics: Taking A Dual Approach To Drug Development
    Genomics & Tissue Phenomics: Taking A Dual Approach To Drug Development

    It can be said that 2014 was the year of genomics. The industry saw several new startups in the area, and Google's venture into the genomics market made a big splash. However, in 2015 the industry is expected to look beyond genes and focus on a dual approach to drug development leveraging data from both the genes and the tissue, particularly in oncology.

  • Sartorius Expands To Meet Growing Needs Of Its Customers
    Sartorius Expands To Meet Growing Needs Of Its Customers

    When Mary Lavin began her career at Sartorius in 1988, when the company set up operations on Long Island, it had combined U.S. sales of $20 million and 40 employees in the states. A lot has changed since then. The company now has over 800 employees in North America and expects 2015 sales to exceed $350 million. But the company is not done growing. On June 2nd, Sartorius had a grand opening ceremony for its new Application Center in Bohemia, NY, which will help the company to continue to meet the needs of its growing customer base.

  • Standardized Extractables Testing Advances Single Use Adoption
    Standardized Extractables Testing Advances Single Use Adoption

    The Standardized Extractables Testing Protocol For Single-Use Systems In Biomanufacturing written by BPOG members last year establishes a foundation from which to create a standardized approach to extractables testing. However, since its release, there have been some questions and discussions about how to effectively implement the protocol.

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UPSTREAM PROCESSING WHITE PAPERS AND CASE STUDIES

  • Accelerating Biopharmaceutical Development From DNA To Drug
    Accelerating Biopharmaceutical Development From DNA To Drug

    The pipeline of biopharmaceutical drugs is rich and becoming increasingly diverse. Many new biologic modalities are being developed as established therapeutic classes move through their lifecycle. Wide arrays of different types of molecules are expected to coexist within product portfolios and manufacturing networks. It is clear that this will have a significant impact on manufacturing facilities. Strategies need to be developed to prepare facilities for these challenges.

  • Live Cell Imaging Of GPCR Dependent Second-Messenger Systems
    Live Cell Imaging Of GPCR Dependent Second-Messenger Systems

    A significant proportion of academic and drug discovery research is devoted towards the elucidation of second messenger signaling cascades resulting from interactions between G-protein coupled receptors (GPCR) and their ligands. By Paul Held Ph. D. and Peter Banks, Ph. D., BioTek Instruments, Inc. and Paul Tewson, Anne Marie Quinn and Thom Hughes, Montana Molecular

  • Semi-Automation Of A Non-Radioactive Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Assay (Part I)
    Semi-Automation Of A Non-Radioactive Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Assay (Part I)

    We describe the use of a non-radioactive, bioluminescent Antibody-Dependent Cell- Mediated Cytotoxicity (ADCC) assay. The protocol is a simple sequential addition of reagents and cells that can be readily automated with a simple, inexpensive pipetting station.

  • A Homogeneous Assay To Quantify Endogenous AKT Phosphorylation In Human Umbilical Vein Endothelial Cells
    A Homogeneous Assay To Quantify Endogenous AKT Phosphorylation In Human Umbilical Vein Endothelial Cells

    AKT is a serine/threonine protein kinase that plays a key role in cellular processes. AKT has become a popular target for drug discovery campaigns, due to the fact that AKT inhibitors may help to treat a number of cancers.

  • Skip Steps In Cell Culturing

    With Cell Culture Flask Adapters, the culture can be centrifuged directly in the flask. Data illustrates that cell yield, cell viability, and endpoint analysis results are comparable when cell cultures are processed traditionally or centrifuged directly in the flask using Cell Culture Flask Adapters.

  • Capture And Purification Of Recombinant Albumin Fusion Proteins Using AlbuPure®
    Capture And Purification Of Recombinant Albumin Fusion Proteins Using AlbuPure®

    Human serum albumin (HSA) has a vast array of applications within the BioPharmaceutical industry including; plasma expansion, formulation excipient, drug delivery, wound healing as well as extending the half-life of a protein drug as a fusion partner.

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UPSTREAM PROCESSING PRODUCTS

Single-Use, Flexible Stirred-Tank Bioreactor System: Xcellerex XDR-10 Single-Use, Flexible Stirred-Tank Bioreactor System: Xcellerex XDR-10

This XDR single-use bioreactor is sized for the benchtop, yet allows smooth scale-up to full production.

Single-Use Cell Culture Bioreactor Systems: Xcellerex XDR Single-Use Cell Culture Bioreactor Systems: Xcellerex XDR

Xcellerex XDR Single-Use Bioreactor Systems provide scalable and robust stirred-tank performance for up to 2000 L in both GMP and non-GMP environments. Functional in batch, fed-batch and perfusion bioreactor modes, they offer smooth transfer from process development to manufacturing scale, with the convenience and cost-effectiveness of single-use technology.

One Film For Your Entire Upstream Production: CX5-14 One Film For Your Entire Upstream Production: CX5-14

Thermo Scientific CX5-14 film is engineered to meet the most demanding requirements of your bioproduction processes.

Single-use Clarification Systems: Sartoclear Dynamics® Single-use Clarification Systems: Sartoclear Dynamics®

Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology.

Mix-Mode Chromatography Resin Mix-Mode Chromatography Resin

Mixed-mode chromatography resin is a top tier selection for the manipulation, purification and handling of molecules; providing an unmatched level of separation properties and resolution. The combination of cation exchange resin and metal affinity resin properties, allows multimodal chromatography to provide an access route for biomolecules to separate and the use of alternative chromatographic methods make these biomolecules seem homogenous.

HyPerforma™ Single-Use Fermentor (S.U.F.) HyPerforma™ Single-Use Fermentor (S.U.F.)

The S.U.F. is engineered for optimal oxygen mass transfer, mixing, and temperature control, and performs comparably to traditional stainless steel systems. Using traditional, fundamental engineering principles, scale-up and process development work is streamlined – offering you cost savings and efficiency. 
 

CELLine™  Bioreactors Advanced Cell Cultivation Devices CELLine™ Bioreactors Advanced Cell Cultivation Devices

In an effort to push science forward, WHEATON is manufacturing  a new line of membrane driven flasks for high density cell culture. The flasks are designed to enhance small scale bio-production for antibody and protein generation.

Sartocheck® 4 Plus Bag Integrity Tester Sartocheck® 4 Plus Bag Integrity Tester

Sartorius introduced the very first Sartocheck® filter integrity tester in 1980. Over the 30-year period of continual enhancement that followed, the Sartocheck® product line evolved into the most sophisticated automated integrity test solution and the preferred choice of critical customers who insist on the best in performance and quality.

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UPSTREAM PROCESSING MULTIMEDIA

Viral Defense From A New Perspective For MVM Contamination Viral Defense From A New Perspective For MVM Contamination

MilliporeSigma has identified a gene target (Slc35A1) that, upon elimination of expression by gene editing, results in a CHO cell line that is resistant to infection by Minute Virus of Mice (MVM). This technology is called Centinel™ Intelligent Virus Defense and it goes beyond viral insurance. It’s an integral component of a sophisticated virus mitigation strategy for preventing, detecting and removing viruses.

Applikon BioSenz Glucose Analyzer Gives Real-Time Glucose Level Measurements In Bioreactors

Lori Clapper talks with Wesley Marner, manager, small-scale technologies, at Applikon.  Wesley expressed how companies desire to get more data out of their bioprocesses, and accomplish that in a more automated fashion.  With that, you will have a better real-time handle on what your process is doing, and better control of the overall performance of your process. He also discussed how Applikon’s BioSenz Glucose Analyzer helps you do just that.

Analyze Microliter Samples In Seconds - NanoDrop Lite

NanoDrop users are thrilled with how easy it is to analyze microliter samples in just seconds. Unlike other microvolume instruments, NanoDrop technology requires no special set up, no consumables, and no dilutions. With the NanoDrop Lite you simply pipette 1 µL, measure, and wipe clean.

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UPSTREAM PROCESSING INDUSTRY NEWS

More Upstream Processing Industry News