Bioprocessing Application Notes & Case Studies
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Advanced In Vitro Duodenal Model For Toxicity Assessment
3/13/2024
Here, we review how an advanced in vitro model closely aligned with the human duodenum was utilized to evaluate the toxicity of indomethacin, a known gastrointestinal toxicant.
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Cytokine-Mediated Inflammation In A Relevant Preclinical Model
3/13/2024
Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.
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The Application Of The Species-Specific Liver-Chip In Predicting Hepatoxicity
3/13/2024
An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.
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Sterilizing Grade Filter Performance With Biologic Drugs
3/11/2024
Here, we analyze the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins and demonstrate how filter selection can impact your process.
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Aggregate Removal From mAbs By Hydrophobic Interaction Chromatography
3/7/2024
Review the results of a study where Hydrophobic Interaction Chromatography (HIC) techniques were used with a resin for the removal of aggregates in the manufacturing of monoclonal antibodies.
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Analysis Of Drug-Excipient Incompatibility In Discovery And Formulation Development
3/7/2024
We analyze drug-excipient incompatibility using a microcalorimeter system equipped with a multi-sample cell capable of simultaneously measuring highly sensitive heat flow data from up to three samples.
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Exosome Isolation By TFF And Size Exclusion Chromatography
3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
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Novel Engineered Plasmids, Optimized HEK293 Cell Line For AAV Productivity
3/5/2024
Lonza has further improved its platform process with the creation of engineered plasmids that afford significantly higher titers and productivity levels compared to standard systems.
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Meet An Optimized Suspension-Based Platform Technology
3/5/2024
The ready-to-use, suspension-based Xcite® Lenti Platform Technology for transient transfection of LVVs eliminates that need to transition from small-scale adherent processes.
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Global BioPharma Saves Reporting Time On ADA Studies
2/29/2024
A flexible solution to save study reporting time has been achieved with a seamless integration with E-WorkBook and the customer’s LIMS.