Bioprocessing Application Notes & Case Studies

  1. Implementing Next-Generation Laboratory Informatics

    Forty-two years ago, Arthur C. Clarke envisioned the HAL 9000, a sentient computer capable of directing a space mission to Jupiter. At the Symyx Symposium in Barcelona(2010), Stephan Taylor, director of project and process optimization systems in process R&D at Bristol-Myers Squibb, envisioned another version of HAL: the Highly Automated Lab, managed by a sentient electronic lab notebook (ELN).

  2. How AstraZeneca Improved Validated Workflows In GMP API Manufacturing

    The reality is that paper is more of a habit than a requirement. AstraZeneca discovered this when they aimed to introduce ELNs to improve the efficiency of their validated workflows for GMP API (active pharmaceutical ingredient) manufacture. Paper and its associated workflows were standard only because they were familiar and had been defined over time to meet the needs of scientists, process engineers and quality control and assurance staffs.

  3. True Scientific Knowledge Management In R&D: Electronic Laboratory Notebooks (ELNs)

    One tool holds a unique position among R&D informatics systems. Unlike other systems, electronic laboratory notebooks (ELNs) both produce data and consume information. An ELN’s ability to capture data, observations, experiences, and context is particularly powerful when combined with other data pipelining tools. The ability to link key pieces of data and mine experiments captured in the ELN for insights fuels true scientific knowledge management. This use case describes the broad organizational benefits that BIOVIA Workbook made possible for a global pharmaceutical company, highlighting how the system is supporting efforts to gain predictive control over key processes in Research and Development.

  4. Biogen And Biovia: Answering Pharma Manufacturing’s Call

    Biogen’s Cambridge Manufacturing Facility leaders assessed their paper-based SOP delivery system. Their findings were that their procedures were inefficient and costly.

  5. Integrate Sterile And Efficient Temperature Control In Downstream Protein Purification

    Bio-therapeutic manufacturing requires precise control of process parameters throughout production to ensure high yield and high quality products that are safe for patient use.

  6. A Comparison Of Single-Use Versus Stainless Steel Systems For Microbial Fermentation

    Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.) is a unique, robust, and purpose-built solution for microbial fermentation applications, offering flexibility, ease-of-use, and efficiency found in single-use systems.

  7. Consistent And Efficient Mixing For Process Liquid Preparations

    The next-generation Thermo Scientific™ HyPerforma™ Single-Use Mixer (S.U.M.) provides enhanced functionality, ease-of-use, and efficiency for critical up- and downstream process liquid preparation. In this study, the 100 L HyPerforma S.U.M. was tested to demonstrate its mixing efficiency.

  8. Improved Scalability Of High-Density Culture For Single-Use Systems

    High-density culture (>40 x 106 cells/mL) strategies reduce processing time and include perfusion, concentrated fed-batch, and intensified seed trains—whereas an N-1 perfusion bioreactor is used to seed a production bioreactor.

  9. Microbial Fermentation Of Proteinase K: Single-Use Vs. Stainless Steel

    The Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.) is a unique and rigorous solution for microbial fermentation applications, offering the flexibility, ease of use, and efficiency found in single-use systems. 

  10. Upstream Cell Culture Manufacturing: Reduce Cost, Increase Quality, Shorten Cycle Time

    Manufacturing biopharmaceutical products on an industrial scale has required scaling up a variety of techniques that were previously only practiced at bench scale. This includes highly technical and notoriously difficult processes such as cell culture; maintaining living cells in a tightly controlled sterile environment.