Bioprocessing Application Notes & Case Studies
-
AAV Process Intensification Using High Salt Lysis And Salt Tolerant Endonuclease
3/25/2024
In the production of adeno-associated virus (AAV) vectors, cell lysis involves challenges addressed through high salt concentrations and a salt-tolerant endonuclease, enhancing titer and infectivity.
-
Find The Right T Cell Expansion And Phenotype Balance For Cell Therapy
3/22/2024
Explore this study that works to determine the optimal concentrations of IL-7 and IL-15 for T cell expansion, as well as how to produce the desired phenotype while requiring less protein.
-
Touch-Free T Cell Expansion With A Fill-And-Forget Workflow
3/22/2024
Explore a bioreactor for large-scale, low-cost immune cell therapy manufacturing paired with a "fill-and-forget" workflow and discover how robust T cell expansion can be achieved.
-
Get Full Control Of Your T Cell Isolation
3/21/2024
This study demonstrates the automated magnetic isolation of CD4/CD8+ cells from fresh or frozen leukapheresis using a functionally closed cell processing system paired with a modular application.
-
Scale Up Strategy For Oncolytic HSV-1 Vector Manufacturing
3/21/2024
Discover how a novel, large-scale production method for herpes simplex virus type-1 vectors has the potential to accelerate the progress of gene therapy and bring it closer to widespread application.
-
Cell Line Development For High-Titer Lentivirus Vector Production
3/21/2024
Explore a groundbreaking method to significantly enhance LV vector yield using engineered HEK293T cells. This approach paves the way for more efficient and large-scale production of LV vectors.
-
Gradient Performance Of The DynaChrom Single-Use Chromatography System
3/18/2024
Explore a single-use chromatography system that introduces micro-efficiencies into the manufacturing workflow process, potentially leading to time and cost savings throughout the production life cycle.
-
Enhanced T Cell Expansion While Maintaining Early Memory Cell Phenotype
3/15/2024
Study the development and performance of this animal origin-free (AOF) T cell culture medium designed for T cell expansion through an experiment comparing it to other AOF or xeno-free basal offerings.
-
Proximal Tubule Kidney-Chip For Modeling Human Physiology
3/14/2024
Discover how an Organ-Chip can be used to create a comprehensive recapitulation of the proximal tubule, addressing the need for more human-relevant preclinical models in the pharmaceutical industry.
-
Duodenum Intestine-Chip For Modeling Human Physiology
3/14/2024
Discover an Intestine-Chip that integrates the robust cell sourcing of organoids with Organs-on-Chips technology to overcome experimental limitations and yield a closer-to-human transcriptomic profile.