White Paper

Viral Vector Vaccine Bioprocessing Handbook

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A live vector vaccine is a vaccine that uses a weakened or harmless microorganism to transport pieces of the antigen in order to stimulate an immune response. Vectored vaccines show promise in their reliability to induce potent cell-mediated immunity, which is essential for complex disease like AIDS, malaria, and cancer among others.

Viral vectors are vehicles that deliver the genetic payload to target cells. Advancements have been made in the vector design to ensure safety of these types of vaccines. In this paper we describe a template to manufacture of adenovirus-based vaccine used in the bioprocessing industry. Compared to the conventional vaccines, adenovirus vector-based vaccines can express a wide range of antigens from virus, bacteria, or protozoan. They elicit long-term immune responses against infectious diseases.

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