Product/Service

Thermo Scientific HyPerforma Integrated Single-Use Bioreactors (S.U.B.)

Source: Thermo Fisher Scientific

Thermo Scientific HyPerforma Single-Use Bioreactor Turnkey System

Our integrated single-use bioreactors are designed as complete out-of-the-box jacketed systems, each paired with an integrated controller and temperature control unit (TCU).

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The vessel is based on the proven Thermo Scientific HyPerforma Single-Use Bioreactor (S.U.B.) mixing technology. The design is ergonomically friendly, and the systems combine unsurpassed flexibility and convenience. The integrated Single-Use Bioreactor. is fully integrated with a Delta-V–based control system and offers immediate utility. The system is specifically designed for users who need rapid setup of a standard system and are often preferred in R&D, early process development, and clinical trial stages.

Integrated Single-Use Bioreactor key system features and benefits: 

  • Cell culture vessel with standard 5:1 turndown ratio
  • Classical geometry and design
  • Preconfigured for rapid on-site setup with left- or right-side options
  • Integrated off-the-shelf S.U.B. systems are available in sizes from 50 – 250 L (non-integrated S.U.B.s are available up to 2,000 L)
  • Delta-V control system optimized for mammalian cell culture
  • Integrated Lauda Temperature Control Unit for optimized heating and cooling
  • Overhead stirred-tank reactor with preassembled single-use agitation assembly in BPC
  • Direct mechanically coupled drive

Benefits and options: 

  • Lead time of 4 weeks or less for delivery
  • Optional cable management system can be integrated separately
  • Factory acceptance test (FAT) completed with each system
  • Site acceptance test (SAT) can be purchased as an option
  • Used in research and development (R&D) and process development (PD) applications
  • Used in cGMP manufacturing

Components of integrated Single-Use Bioreactors
The integrated bioreactor systems consist of four primary components:
1.Vessel or outer container—includes a mixer motor, load cells, and water jacket, all on a mobile cart (except 2,000 L size)
2.Single-Use Bioreactor BioProcess Container (bag)—the presterilized, ready-to-use single-use consumable required for use with the bioreactor hardware
3.TCU—monitors the heating and cooling of the medium during the cell culture run
4.Control system with touch screen monitor—used for process management of critical parameters (e.g., temperature, pH, dissolved oxygen, overlay pressure, vessel mass, liquid pumps, vent heaters, and gas mass flow controllers) and logs process values and settings

 

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