Application Note

The Benefits Of Using Mixed-Mode Chromatography Sorbents In A MAb Purification Process

Source: Pall Biotech
Pall: provider of filtration, purification and separation technologies

The benefits of the unique selectivity and chemical stability offered by mixed-mode chromatography for the purification of monoclonal antibodies (MAbs) are well established. Rapid determination of optimum operating conditions earlier in process development maximizes the value of these industrial adsorbents.

This study describes the use of low cost, easy-to-use bench technology to perform high throughput screening (HTS) to optimize separation conditions for the purification of monoclonal antibody using Pall mixedmode chromatography sorbents.