Webinar | March 19, 2018

Streamlining Biopharmaceutical Cell Line Development

Source: MilliporeSigma

 CHO cells with their unique characteristics, represent the major expression system within the biopharmaceutical industry. However, one of the major challenges in cell line development is to identify those rare, high-producing clones in a huge population of non-expressing or low-expressing cell lines. This leads to laborious and time consuming cell line development processes. This webinar will educate the audience about challenges faced with traditional expression systems and how the CHO cell line with the glutamine synthethase knock-out via Zinc Finger Nucleases provides benefits for fast and efficient cell line development as well as stable and high titer expression. We will explore additional cell line engineering targets that can be modified to engineer a cell line that mitigates risks and removes bottlenecks throughout the biopharmaceutical process.

In this webinar, you will learn:

  • What are the benefits of using an optimized/engineered expression system?
  • What can be done throughout the cell line development process to mitigate risks and remove bottlenecks?
  • Applications of cell line engineering for further upstream biopharmaceutical enhancements.