Strategies such as process intensification have the potential to create shorter lead times, reduce plant footprint, increase flexibility, and reduce cost of goods (COGs). Upstream processes can be intensified using a number of strategies, which can deliver significant improvements in speed, flexibility, and reliability. In this white paper we explore two of these approaches — high cell density cryopreservation (HCDC) and the use of a perfused seed train including a specially designed expansion medium.
Some leaders in the pharma, biopharma, and medical device industries believe hiring consultants is quicker and more efficient than hiring a full-time employee. Does this thinking fail to factor in the investment required for thorough recruiting and training to ensure a successful engagement?
By Bruce C. Simpson,Thermo Fisher Scientific
The most common storage is ultralow temperature storage, but the fastest growing is cryogenic, in vapor phase liquid nitrogen. This transition is huge. Chain of temperature and custody data is imperative.
By Prof. Rikinari Hanayama, Kanazawa University Graduate School of Medical Sciences
Gain an understanding of exosomes, which are recently attracting the attention of researchers as new mediators of cell-cell communication transporting biomolecules such as lipids, proteins, and RNAs in vivo.
To investigate the chemical challenges that can be overcome by the right choice of the linker, we have explored the influence of a variety of polyethylene glycol (PEG) linkers on the structure of a model cysteine-bioconjugate.
Scaling-up liquid formulations can present a number of challenges. Learn about potential formulation and filling issues when transitioning a liquid formulation from feasibility through commercialization.