Newsletter | October 15, 2021

10.15.21 -- Purification Service Providers & Suppliers Ready To Help

Pegasus™ Protect Virus Prefilters And Pegasus Prime Virus Removal Filters

Pegasus Protect virus prefiltration combines with Pegasus Prime virus filtration to deliver the first gamma-sterilized pre-filter & virus filter combination. Together, these simplify process development, validation and operations while saving time and delivering improved process economy.

Liquid Chromatography Systems

At Asahi Kasei Bioprocess, our engineers understand that there is no “one size fits all” chromatography system in the world of large-scale purification. Asahi Kasei Bioprocess offers a Liquid Chromatography (LC) System platform that is configurable to the unique purification requirements of your molecule. Systems are available in capacities suitable for process development/scale-up, clinical manufacturing and commercial manufacturing.

J.T.Baker BAKERBOND PROchievA Recombinant Protein A Affinity Chromatography Resin

Enabled by a new, proprietary protein A derived ligand, J.T.Baker BAKERBOND PROchievA provides best-in-class purification performance for monoclonal antibodies, Fc-fusion proteins, and IgG antibody type molecules.

Got Purification Troubles? Get The Best HCP And Aggregate Clearance During mAb Purification

Are you unable to efficiently reduce process- and product-related impurities during your purification process? Screening multiple resins helps you select the right one for your purification success.

PX2+ Photometric Transmitter

Process monitoring equipment is a great investment as economic benefits arise from greater process control  and less waste. The PX2+ Photometric Transmitter is designed for use in continuous process monitoring applications in a variety of industries. The PX2+ is a highly sensitive, easy to use, and compact instrument capable of making absorbance or fluorescence measurements.

Hyper-Productivity In Your mAb Purification Step

Learn how a tenfold increase in productivity of 200 g/L/h compared to the industry norm was possible through an intensified Protein A capture process.

Pellicon® Capsules With Ultracel® Membrane Performance Guide

Interested in evaluating single-use TFF capsules for your ultrafiltration and diafiltration applications? This easy-to-use guide provides you with general guidelines on various performance aspects of Pellicon® Capsules and application studies that should be considered and evaluated for your particular process and feedstream.

In-Process Control Of pDNA Production On CIMac™ pDNA Analytical Column

As the demand for plasmid DNA (pDNA) based gene therapy and vaccines increases, large-scale, cost-effective, and reproducible pDNA production is required. The key to success is a real-time in-process control method that ensures a high percentage of supercoiled pDNA in the final product. Read how the CIMac™ pDNA Analytical Column allows the monitoring of degradation products (open circular and linear pDNA), the removal of impurities (RNA), and ensures that each production step yields the amount of supercoiled pDNA anticipated.

HiTrap And HiScreen Fibro PrismA Units

More targeted patient populations and smaller manufacturing batch sizes are driving the demand for increased process efficiency and flexible multiproduct facilities in monoclonal antibody (mAb) manufacturing. To help meet these needs, we
developed ready-to-use Fibro PrismA units for capturing mAbs and Fc-containing recombinant proteins.

Residual Protein A For Bioprocessing Applications

Most therapeutic monoclonal antibodies (mAbs) are isolated from cell culture media using Protein A chromatography. During purification, Protein A can leach from the solid phase, ending up in the purified product. This can be problematic as regulatory guidelines dictate that detection and reduction of residual Protein A are necessary to obviate potential immunogenic consequences in vivo.  ProteinSimple’s Wes™ provides a powerful solution by bringing immunoassay into a capillary electrophoresis format.

Protein A Mix-N-Go™ ELISA Kits

Mix-N-Go™ ELISA kits are designed to perform with most natural and recombinant Protein A constructs and incorporate the revolutionary single step sample treatment procedure. These kits also reduce the complexity of the assay and time to result while increasing the robustness of the method over traditional Protein A ELISAs.