This webinar serves as an overview of key aspects associated with pDADMAC flocculation implementation. Topics include the identification of optimal dosage and method of pDADMAC addition, as well as an assessment of the impact of flocculation process parameters such as mixing times and mixing speeds. In addition, other clarification aspects including Clarisolve® depth filter scalability, impact on sterile filter capacity and any potential continued precipitation in presence of flocculant are addressed. Another key aspect for GMP implementation is successful cleaning validation. In this presentation, we also provide data for cleanability of stainless steel surfaces soiled with pDADMAC flocculated cell culture.