12.03.20 -- Optimize And Scale-Up Your Process With Single-Use Bioprocessing Equipment

 
 
 
 
 

Improve Product Yield, Efficiently Scale Up, And Maintain Sterility Throughout Your Process With Single-Use Fermenters

The Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.) is pioneering the single-use technology market by delivering a unique and rigorous solution for microbial fermentation applications while offering the flexibility, ease of use, and efficiency found in single-use systems. These fermenters have been optimized for oxygen mass transfer, mixing, and temperature control. Using traditional, fundamental engineering principles, scale-up and process development work is streamlined – offering you cost savings and efficiency.

9 Reasons To Consider A Single-Use Fermentor In Your Process

Historically, the rigorous performance demands of industrial scale microbial fermentation processes have required the use of traditional stainless steel cleaning-in-place / sterilization-in-place (CIP/SIP) fermentor vessels. The HyPerforma S.U.F. delivers scalability and meets the requirements of dense, rapidly growing microbial cultures used in modern fermentation production facilities and offers many unique benefits when developing new molecules in microbial systems, revamping and validating older processes, or upgrading aging equipment. Read this article to identify 9 reasons to consider a single-use fermentor in your process.
 
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End-User Evaluation Of The Hyperforma Single-Use Fermentors And Scale-Down Model For Plasmid DNA Production

In moving processes from bench to pilot and ultimately production fermentors, it is critical to have a reliable scale-down model. The purpose of a scale-down model is to demonstrate at the benchtop level what can be achieved in production-scale fermentors. Scale-down models can vary depending on the media, strain, and process conditions. In this case, a customer wanted a scale-down model of the HyPerforma S.U.F. in order to establish what fermentation processes could be scaled into the S.U.F., in particular for the production of plasmid DNA.
 
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Scale-Up And Technology Transfer From 100 L SIP/CIP Vessel To A 300 L S.U.F.

A collaborative study between Thermo Fisher Scientific and a customer was conducted with the objective of taking an existing, smaller preclinical E. coli process previously performed in HyPerforma 300 S.U.F. to demonstrate equivalent growth and product yield at a larger scale and to identify changes in the process step to accommodate tech transfer using single-use products.
 
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Hyperforma S.U.F. Meets The High Demand Of Industrial Microbiology

The HyPerforma S.U.F. system uses traditional stainless steel fermentor engineering principles to meet the high demands of industrial microbiology with efficient mass transfer, mixing, and temperature control. Watch this technical video animation to learn how this fermentor is the first of its kind, designed specifically for microbial fermentation.
 
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Want to learn more about HyPerforma Single-Use Fermentors?
 
The HyPerforma S.U.F. is designed for the unique requirements of microbial fermentation, while maintaining flexibility, ease of use, and efficiency found in single-use systems. We look forward to talking to you about your single-use fermentor needs.
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