Due to their structure, plasmids can pass through pores smaller than their apparent molecular weight. DNA can be shear-sensitive and tends to increase with plasmid size, which can result in degradation and reduction of overall yield. Learn how optimization of hydraulic parameters can help you achieve the desired plasmid purity, formulation, and concentration specifications.
Learn about a first-of-its-kind spiral-wound TFF filter engineered to provide linear scalability and designed for efficient single-use UF/DF. Explore methodology and experimental results in the performance evaluation of this device versus hollow fibers for UF/DF of viral vectors along with the impact of either filter type on a TFF process.
In downstream manufacturing of AAV, tangential flow filtration (TFF) is an essential operation. Here, we evaluate the scalability performance of Pellicon® Capsule, a first-of-its-kind spiral-wound TFF device, and Pellicon® XL 50 cassette.
Ideal for single-use ultrafiltration and diafiltration of viral gene therapy and vaccine products, Pellicon® Capsules are first-of-their-kind spiral-wound TFF filters that offer consistent performance and linear scalability at any manufacturing stage.
Discover innovative single-use tangential flow filtration (TFF) devices for streamlined bioprocessing. Pellicon® Capsules with Ultracel® membrane arethe ideal TFF devices for the filtration of solutions that require single-use capabilities.
