Newsletter | February 7, 2020

02.07.20 -- Faster Assessment Of Monoclonal Antibody Functionality

 
Accelerate Biopharmaceutical Development With Novel Analytical Techniques
 
This article explains how using an Octet-based Fc receptor panel may help developers achieve a faster assessment of monoclonal antibody functionality, well before the final molecule is selected.
Enable Oral Delivery Of Synthetic Oligosaccharides
 
Due to their poor oral bioavailability, oligosaccharides — along with most pharmaceutical macromolecules — are formulated as solutions or suspensions and delivered by invasive intravenous (IV) or subcutaneous injection. This case study demonstrates how OptiGel Biotechnology significantly increases oral bioavailability of a synthetic oligosaccharide, thus enabling oral conversion.
A Solution To Ensure Quantity & Quality Of The Excipient Polysorbate-80 In Drug Formulations
 
Polysorbate-80 (PS-80) is a surfactant commonly used as an excipient to improve API stability. However, degradation of PS-80 can lead to decreased drug potency or stability, and there is inconsistency in the quality and composition of PS-80 provided by different vendors. Outlined here is a two-method solution to evaluate one such excipient (PS-80) for quantity and quality.
ICP-MS Analysis Of Multiple Trace Elements In Industrial Cell Lines
 
Characterization of trace elements is important for upstream process development and batch quality control. This poster outlines a strategy using inductively coupled plasma-mass spectrometry (ICP-MS) to conduct trace-level multiple analysis.