Chromassette® is a high performance, rectangular, stackable, cassette device that can be easily packed with any chromatography resin. Its unique supported bed offers the reliability and performance of a column together with improved pressure-flow properties which are not altered by scaling. As such, it readily meets today’s bio-separation scale up demands for improved ease of use. Comparisons of Chromassette with similar dimensioned columns indicate that Chromassette can offer improved productivity. This application note is based on an internal comparison of a commercial cation exchange resin packed in a 1 cm diameter x 6 cm bed height column and a 6 cm high Chromassette device. Results suggest comparable separation performance with the ability to be operated at much faster flow rates and thereby higher productivities.