Comparability GXCore vs. G3Lab Bioprocess Controllers For CHO Cultivations - Users Study

Here we describe the cultivation of an immunoglobulin G (IgG)-expressing CHO cell line using the new Thermo Scientific HyPerforma GXCore Bioprocess Controller in conjunction with a Thermo Scientific HyPerforma Glass Bioreactor, featuring a maximum working volume of 2 L. The same process was also carried out using a Thermo Scientific HyPerforma G3Lab Bioprocess Controller for comparison. Two fed-batch cultivations were performed with each system, resulting in highly similar growth and IgG production profiles. At the end of the 14-day process, IgG titers of 2.79 ± 0.045 g/L were reached.