Combine Multiple Purification Steps Into One With The 3M™ Polisher ST

Producing Monoclonal antibodies (mAbs) and recombinant therapeutic proteins consistently at a commercial scale is both complex and costly ($300-$400 Million). 3M™ Polisher ST technology offers a sand box approach that provides several advantages including the ability to anticipate process yield, product purity and quality.

3M™ Polisher ST offers not only economic benefits and versatility, but it also has specific functional advantages over equivalent packed-bed columns.

• Convenience

There is no cleaning or validation, no packing, re-packing and recycling.

• Small footprint

A 16” inch diameter production scale capsule of 1.6m² surface area of Q functional and guanidinium media can replace a packed column of 80 liters. Capsules can be stacked for even higher loadings.

• Economics

Use of one fifth (20%) of the buffer volume compared to a column of equal capacity, saving time and money. Lower buffer volumes in the purification process drive down wastewater that needs to be handled for disposal.