Product/Service

Chromatography Media

Source: Cytiva
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Cytiva's range of chromatography media and systems cover several different types of liquid chromatography at all scales of purification from research to process-scale.

MabSelect SuRe LX

MabSelect SuRe LX is an alkali-stabilized, protein A-derived affinity medium with a binding capacity for monoclonal antibodies (MAbs) exceeding that of MabSelect SuRe at longer residence times. As an example, at 6 min residence time, the dynamic binding capacity of MabSelect SuRe LX for human IgG is approximately 60 g/l. This special combination of high binding capacity plus alkaline stability gives manufacturers of MAbs many opportunities to improve process economics and product quality.

Capto ImpRes

Capto SP ImpRes and Capto Q ImpRes are strong cation and strong anion exchangers for the high-throughput intermediate purification and polishing steps of a wide range of biomolecules.

Benefits:

  • High-resolution intermediate purification and polishing based
  • Flexible process design
  • Easy to optimize and scale up
  • Higher manufacturing productivity
  • Security of supply and comprehensive regulatory support

Capto L

Capto L is an affinity chromatography medium for the process-scale capture of a broad range of antibodies and antibody fragments. It combines a rigid, high-flow agarose matrix with the immunoglobulin-binding protein L ligand. Capto L is therefore suitable for capture of a wide range of antibody fragments such as Fabs, single-chain variable fragments (scFv), and domain antibodies (dAbs, in addition to binding all classes of Ig (IgG, IgM, IgA, IgE and IgD).

Capto Core

Capto Core 700 is a multimodal chromatography medium that is designed for flowthrough purification of large proteins or viruses in vaccine processes. The multimodal property of the ligand in the core ensures strong binding with most impurities over a wide range of pH and salt concentration.

Benefits:

  • Enabling significantly higher sample load
  • Enabling higher flow rates
  • Ensuring straightforward optimization and scale-up

 

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