Application Note

Cell Culture Media Filtration: Filter Selection And Sizing

Millipore2

As the global demand for biopharmaceuticals continues to rise, bioprocessing is evolving with a focus on maximizing productivity upstream through improvements in cell line development and cell culture media optimization. However, efficiently processing cell culture media can be challenging as many of these new media are highly concentrated and complex, with components that may lead to premature fouling of membrane filters.

Membrane filtration is a robust, easy-to-implement, time-tested solution for processing cell culture media that significantly reduces the risk of bioreactor contamination. Selecting a membrane filter for processing cell culture media is influenced by the desired level of microbial retention, compatibility of the filter materials with the fluid stream, and the filter capacity for your specific media.

Upstream bioprocessing is evolving with improvements in cell line development and cell culture media optimization. This application note provides an overview of different filtration options in terms of microbial retention and filtration capacity and provides filter sizing recommendations for MilliporeSigma catalog media and additives. Increased understanding of these different criteria should help biomanufacturers select the right filter for their process needs.

VIEW THE APPLICATION NOTE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of BioProcess Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
I'm interested in newsletter subscriptions.
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: