Newsletter | February 5, 2020

02.05.20 -- CAR T-Cell Therapy In Non-Hodgkin's Lymphoma: Where Do We Go From Here?

  Enabling Vaccine Production: Solving Challenges Together

Efficient and cost-effective manufacturing of vaccines is one of the toughest problems in the life sciences. We actively collaborate with academia, vaccine researchers, and manufacturers to develop and optimize innovative tools, processes, and strategies to resolve bottlenecks and accelerate the availability of vaccines. In this e-book you will find a series of case studies highlighting our recent collaborations with organizations and thought leaders on the front lines of the battle against these challenging pathogens.

Featured Editorial
Non-Hodgkin Lymphoma CAR T-Cell Therapy: Where Do We Go From Here?
By Sorcha Cassidy, Ph.D., and Rachel Webster, D.Phil., DRG

Following the success of Kite/Gilead’s Yescarta and Novartis’s Kymriah in treating relapsed or refractory diffuse large B-cell lymphoma, key players are pursuing therapies in earlier treatment settings and in mantle cell lymphoma, chronic lymphocytic leukemia, and follicular lymphoma.

Nickels And Dimes: What To Do When Your CDMO Charges You Unexpected Fees
By Barbara Berglund, COO, CMC Turnkey Solutions

In many cases, the business development and sales teams from your organization and the contract service provider work separately. What happens when the invoices have unexpected costs?

Industry Insights
Complex Molecule Development: Early Considerations To Avoid Failing Later
Article | By Andreas Stolle, Ph.D., and Peter Poechlauer, Ph.D., Thermo Fisher Scientific

How to understand and prepare for challenges early in development to avoid bottlenecks that significantly slow production and delay a drug’s time-to-market.

Dancing In The Bioprocessing Ballroom: Voices Of Experience
Article | By T. Page, Ph.D., Fujifilm Diosynth Biotechnologies, LLC, and P. Galliher, GE Healthcare

Single-use technology is well-established and made its way into commercial licensed facilities, but there is more innovation in this field that will enhance its versatility into new markets and technologies.

Early Product Characterization Mitigates Risks In Biologics Development
White Paper | By Daniel Galbraith, Ph.D., MilliporeSigma (Product Characterization)

The relationship between physicochemical profile and biological activity — and how this relationship affects clinical performance — is key to making informed decisions, accelerating development, and reducing risk.

The Roadmap To Outsourcing Vial Fill/Finish
Article | Argonaut Manufacturing Services

Outsourcing a fill/finish project can be a challenging journey without a formal guide to the “right” path. Several key milestones along the way determine your outcome. This article will guide you through them.

The Next Level: Why Move To A Bioreactor?
Article | Eppendorf

Moving beyond the incubator and shaker to bioreactors and fermentors enables ideal environments for cellular reproduction and product formation, increasing experimental yields and enhancing reproducibility.

Single Use: The Optimal Solution To Store And Ship Frozen Substances
Article | Single Use Support

As geographic detachment of biopharmaceutical substance processing from final production becomes standard, freezing biopharmaceutical substances in single-use containers offers several advantages.

Is Your Complex Formulation Process Set Up For Success?
White Paper | Ajinomoto Bio-Pharma Services

Any company pursuing a drug delivery system that involves a complex formulation must be prepared for the requirements around this type of drug development to achieve successful scale-up.

Rapid Global Characterization Of Ig G1 Following Oxidative Stress
Poster | Catalent

In this poster we describe a method for rapid and consistent global characterization of leachable metals or peroxide-stressed mAbs using two independent protease digestions.

Single-Use Technologies For BDS Freeze/Ship/Thaw
Webinar | Entegris, Inc.

Mike Johnson, Johannes Kirchmair (SUS), explains the importance of having a complete, cold-resistant solution of bags, tubing, connectors, and shells.

Life Science Leader Magazine

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