Newsletter | September 27, 2022

09.27.22 -- Bioseparation Innovation Standardized

 
Innovation Standardized: Bioseparation Methods For Biotherapeutics
 

The goal of biopharmaceutical development is to deliver high quality, safe, and efficacious treatments to patients. Reduced risk and increased efficiency afforded by appropriate standardization serves this goal. This article discusses the most impactful standards in liquid chromatography (LC) for biotherapeutics.

Selecting A Reversed-Phase Column For The Peptide Mapping Analysis Of A Biotherapeutic Protein
 

Selecting a column for a peptide mapping separation is decidedly difficult, as there are a multitude of columns provided by numerous manufacturers. In this study we review reversed-phase (RP) column selection considerations for peptide mapping applied to the routine characterization and analysis of biotherapeutic proteins.

Improving Released N-Glycan Analysis In Biotherapeutic Development Using Premier Solution With HPS Technology
 

Characterization and monitoring of glycosylation are necessary during the development and manufacturing of biotherapeutics to ensure that drug products are consistent, safe, and efficacious. Explore how we improved releasing N-glycan analysis in biotherapeutic development, which can help develop robust and unbiased glycan assays for biotherapeutic development, manufacture, and release.

Method Migration Of Size-Exclusion And Ion-Exchange Methods For Monoclonal Antibody Analysis
 

This work demonstrates that legacy SEC and IEX methods could be migrated from an Alliance HPLC System to our system with negligible differences in retention time and peak area percent. Discover how combining this system with modern UHPLC columns could make data more accurately interpreted through greater efficiency, selectivity, and enhanced resolution.

Solutions
MaxPeak Premier Columns For Protein SEC Analysis

MaxPeak™ Premier Columns utilize MaxPeak High Performance Surfaces that are designed to increase analyte recovery, sensitivity, and reproducibility by minimizing analyte/surface interactions that can lead to sample losses.

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