Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. This article describes the further development of a two-step purification of a bsAb.
A single-step downstream process using protein A chromatography to purify a bispecific antibody (BsAb) in early screening has been successfully developed to replace an existing-three step process.
Purification of antibody fragments isn't as straightforward as for mAbs — fragments show wider variation in binding affinities and can be trickier to separate from impurities. Review some purification approaches that can help you harness the potential of antibody fragments.
Choosing a suitable resin for your purification needs doesn't have to be daunting. Learn more about how to select the right resin for your antibody variant purification project.
A free interactive course gives an overview of monoclonal antibodies (mAbs) and current variants used and developed in academia and industry. After completion, you'll be familiar with common antibody variants and their characteristics, as well as gain insights to why bsAbs have such potential as future biotherapeutics.
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