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  • Pfanstiehl Sheds Ferro Corp. For Greater Investment & Growth
    Pfanstiehl Sheds Ferro Corp. For Greater Investment & Growth

    After operating under the Ferro umbrella for 13 years, Ferro Pfanstiehl Laboratories was purchased by PLI Holdings, an affiliate of Med Opportunity Partners (MEDOP). James Breckenridge, founding member of MEDOP, and Cynthis Kerker, president of Pfanstiehl, discuss why the acquisition is good news for the future growth of Pfanstiehl, and how the company's products, focus on quality, and SafeBridge certification made them a good fit with MEDOPs other strategic partners.

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Single Use Biopharmaceutical Powder Handling Equipment

Single Use Biopharmaceutical Powder Handling Equipment

ILC Dover brings a unique history and skill set to the biopharmaceutical industry, particularly single use biopharmaceutical powder handling and containment equipment.

Supporting Advances In MAb Process Development And Manufacturing

Supporting Advances In MAb Process Development And Manufacturing

GE Healthcare is a $17 billion unit of the General Electric Company (NYSE:GE), employing more than 46 000 people worldwide.

SciLog MabTec®

SciLog MabTec®

The SciLog MabTec® is a automated high density cell culture system.

Single-Use And Ready-To-Use Biopharmaceutical Products

Single-Use And Ready-To-Use Biopharmaceutical Products

Biopharmaceutical development and manufacturing demands scalable processes that can be quickly developed and smoothly transferred to production. GE Healthcare Life Sciences’ single-use and ready-to-use technologies, ReadyToProcess™ and Xcellerex™, play a crucial role in providing the flexibility to support multi-product facilities. They deliver process time savings by removing steps such as cleaning, cleaning-validation, filter prewashing and column packing, allowing faster start-up and easier changeover between products.

Cartridges and Elements

Cartridges and Elements

Product sterilization using the vacuum autoclave method is a critical process demanding the highest performance standards for equipment and precise quality control procedures.

Syringe Filters

Syringe Filters

The Mini Kleenpak capsule format is designed for use in the laboratory. As part of the Pall UpScale Program of scalable filter products, these filter capsules feature the lowest surface area for a pleated filter unit and a very small hold up volume, making it ideal for filtering small quantities of fluids (up to 100 mL) with minimal losses.

Biopharmaceutical Cast Film

Biopharmaceutical Cast Film

Facilitate a more efficient biopharmaceutical production process through Pall’s Allegro™ systems. These systems are employed throughout the Active Pharmaceutical Ingredient (API) production process to hold and process bulk product as well as to manage and supply peripheral fluids around unit operations, such as cell culture media, buffer and cleaning solutions.

Hardware

Hardware

Biopharma manufacturing processes are comprised of a series of operations — from mixing, chromatography, to liquid transport. Pall provides hardware and workstations to optimize each operation, as well as consultancy services to provide solutions, validation, and technical support to help manage your procedures.

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Formulation

Formulation in bioresearch is directly associated with pharmaceutical research and development. It is the practice of combining different chemical substances that include the active medical drug. This combination of drug and chemicals is tweaked until they have a final medicinal formulation that can be tested and receive final approval for large-scale market use.

The object of pre-formulation and formulation is to develop a stable preparation of a specific drug that is acceptable for human consumption. All drugs, by necessity, contain other chemicals.  In order to put a drug into a capsule or tablet form it requires a variety of substances other than the drug itself. Formulation is needed to ensure that the drug will work when combined with these other substances.

It may surprise you to know that most formulations are not complete until after Phase III clinical trials are in progress or completed. All the early trials test drug stability, and drug load, which is the ratio of active drug to the total content of the actual dose.

Formulation studies address a variety of issues includinggrain size, pH (acidic or alkaline), solubility, and polymorphism (the ability of a drug to exist in more than one form like liquid and capsule).  Other items formulation addresses is taste, appearance, tablet hardness and tablet or capsule disintegration.

Another aspect of formulation is testing how humidity, temperature, oxidation, ultraviolet light or visible light affects the formulation. The formula must be stable and not degrade under all of the different environmental factors.

Formulation involves a lot of experimenting with different blends of materials and drugs, but is absolutely crucial for the development of effective, safe, stable, oral drugs, and topical ointments.