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Single Molecule Measurement: Best Practices In Biomarker Detection
Single Molecule Measurement: Best Practices In Biomarker Detection

By Mark Roskey, Vice President and General Manager, Applications and Reagents 

The human genome encodes thousands of secreted proteins, each of which is an actor in the delicate biochemical balance of diagnostics. Even a slight change in any one of these proteins can mean the difference between sickness and health. Such a change also provides a critical window into the body and helps to direct diagnosis and treatment, however, the vast majority of secreted proteins are present in concentrations well below what conventional technologies can measure, and their role in human health is poorly understood. Researchers have continued to seek ways to detect and diagnose earlier and more accurately through protein detection, and have been unsuccessful at doing so – until now.

  • Efficient and Cost-Effective Removal Of Residual Endotoxin

    Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell culture expression systems such as E. coli. By Ben Galarza, Jason Shipp, Buzz Lobbezoo, Jennie Walden and Steve Burton, ProMetic BioSciences Ltd

  • Hamilton Robotics Launches Highly Flexible PCR Setup Workstation
    Hamilton Robotics Launches Highly Flexible PCR Setup Workstation

    Hamilton Robotics introduces the PCR setup STARlet, the first automated liquid handling system flexible enough to accommodate any DNA amplification reagent kit, from simple setups and small budgets to highly demanding workflows.

  • BioReliance Acquires Rights To Big Blue Colonies And Cell Lines From Agilent

    Sigma-Aldrich Corporation recently announced that BioReliance, the biologics and early development services business under SAFC, has signed an agreement to acquire the colonies required for the Big Blue transgenic rodent mutation (TRM) assay and to obtain a license to its associated trademark from Agilent Technologies.

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Automated Incubator for Assays: BioSpa 8 Automated Incubator for Assays: BioSpa 8

BioSpa 8 Automated Incubator links BioTek readers or imagers together with washers and dispensers for full workflow automation of up to 8 microplates. Real time control and continuous temperature, CO2/O2 and humidity level monitoring, along with lid handling ensure an ideal environment for cell cultures during all experiment stages, with minimal manual intervention. BioSpa’s software, which features customizable text or email notifications and alerts, also relieves the need for onsite monitoring. The software’s session timelines and environmental reports allow quick scrutiny of the process and system status. BioSpa 8 automates assay workflows by repeated manipulation and storage of microplates containing live cells or temperature sensitive reagents. Link one washer or dispenser, one plate reader or imager, or one of each for start-to-finish workflow automation. BioSpa 8 is ideal for efficient automation of short or long-term cell based and other temperature, gas and humidity sensitive processes.

Exome Isolation Kit: ExoCap™ Exome Isolation Kit: ExoCap™

ExoCap™ is a kit for exosome isolation and enrichment designed and optimized for use with serum, plasma and cell culture supernatants. Exosomes are extracellular vesicles secreted by most cell types that contain marker proteins and microRNAs. This kit consists of magnetic particles coupled with antibodies that recognize the exosome surface antigens (CD9, CD63, CD81, or EpCAM), treatment buffer, washing/dilution buffer, and exosome elution buffer.

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Assay Workflow Automation: Liquid Handling, Reading and Imaging Together Assay Workflow Automation: Liquid Handling, Reading and Imaging Together

Thanks for your interest in BioSpa™ 8 Automated Incubator. We are excited to share the following product demonstrations with you so you can see how BioSpa links liquid handling, reading and imaging together for unattended workflow automation. We’ll provide examples of typical assay workflows to help you understand exactly how BioSpa can help you take control of your cell assays.

Easily Switch Between Washing And Filtration With An Interchangeable Microplate Washer

The Hydroflex microplate washer is a modular and upgradeable platform is ideal for a wide range of cell-, enzyme- and DNA-based applications in academia, biotech, pharma and clinical diagnostics, reflecting over 30 years of Tecan expertise in advanced liquid handling.

How The Infinite M100® PRO Uses Monochromator Innovations For Microplate Reading

Tecan's Inifinte M1000 PRO microplate reader has Quad4 Monochromators technology that uses excitation monochromators to enable good performance over the whole wavelength spectrum.

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