BIOMANUFACTURING FEATURED ARTICLES
A Novel In Vitro Glycosylation Approach For Difficult PTMs
Post-translational modifications of membrane proteins have been historically challenging. Research shows how an in vitro approach brings stability and predictability.
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![GettyImages-1214112149-lab-team-collaboration-research]( "The Hidden Challenges Of ADC Manufacturing - And How To Overcome Them")
The Hidden Challenges Of ADC Manufacturing - And How To Overcome ThemADC manufacturing requires specialized expertise, single‑use systems, precise filtration, aseptic filling, and integrated lyophilization to ensure stability, safety, and consistent clinical‑grade production.
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![SUS - microbial-fermentation-manufacturing-single-use-support]( "Evolving Methods Of Bulk Freezing")
Evolving Methods Of Bulk FreezingLearn how the transition to plate-based freezing with single-use technologies improves scalability and contamination control while ensuring uniform thermal transfer for high-value bulk drug substances.
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![AugustBio_Reshoring_Fixed]( "How Reshoring, GLP-1s, And Supply Chain Security Are Transforming CDMOs")
How Reshoring, GLP-1s, And Supply Chain Security Are Transforming CDMOsExplore how reshoring, GLP-1 capacity demands, and integrated U.S.-based manufacturing models are reshaping CDMO partnerships in a rapidly evolving pharmaceutical market.
BIOMANUFACTURING WHITE PAPERS & CASE STUDIES
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![Multi pipette, sample preparation, bioassay, in vitro cell-GettyImages-2058885436]( "A Comprehensive Blueprint For In Vitro Glycoengineering Adoption")
A Comprehensive Blueprint For In Vitro Glycoengineering AdoptionIn vitro glycoengineering enables precise control of therapeutic protein glycosylation, streamlining product consistency and development through a phased, risk-managed integration after initial purification.
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![mRNA GettyImages-1356994684]( "Levers To Optimize The IVT Reaction For Increased mRNA Yield")
Levers To Optimize The IVT Reaction For Increased mRNA YieldMastering IVT yield requires balancing magnesium and nucleotide ratios. Learn how specific buffers and pyrophosphatase optimize mRNA synthesis for scalable, high-quality therapeutic production.
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![nanoparticles-drug molecule-GettyImages-1428647836]( "Accelerate LNP Manufacturing With Automated Process Development")
Accelerate LNP Manufacturing With Automated Process DevelopmentManual LNP formulation introduces process variability that threatens particle quality and yield. As programs scale toward clinical production, maintaining strict control over CQAs becomes essential.
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![GettyImages-1807380795-analytics-cell-analysis-laboratory]( "Oligonucleotide Purification And Synthesis")
Oligonucleotide Purification And SynthesisExamine how a 21‑mer oligo was synthesized and purified through systematic resin screening, method optimization, and successful scale‑up to build reliable, high‑purity chromatography workflows.
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![GettyImages-1185624320-scientist-lab-smiling]( "Selecting A CDMO For Custom Activated PEGs")
Selecting A CDMO For Custom Activated PEGsCustom-activated PEGs require thoughtful planning and precise analytical control. Discover key considerations for selecting a partner capable of supporting scalable, compliant PEGylation.
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![GettyImages-1371993517-syringe-vial-mask-vaccine-inject]( "Advancing Chronic Care Through GLP‑1 Innovation")
Advancing Chronic Care Through GLP‑1 InnovationGLP‑1 therapies are changing injectable care and driving rapid progress in delivery and manufacturing. See how patient needs, emerging tech, and regulations are reshaping chronic treatment.
BIOMANUFACTURING PRODUCTS
Ensure efficiency in your upstream and downstream biopharma workflows with Charter Medical’s biological fluid management solutions.
From early-stage research to commercial-scale production, Charter Medical delivers integrated solutions that streamline your biopharma workflows.
As advanced therapy manufacturing evolves, maintaining the integrity of biological materials during cryopreservation steps is ever more critical.
Optimize single-use solutions for cryopreservation by engaging in studies that focus on specific timepoints and conditions pertaining to therapy storage, containment/protection, and transportation.
Charter Medical’s DEHP-free CryoProtect™ Bio-Containers are designed for intermediate, final fill, storage, and transport in bioprocessing applications using compatible freezing cassettes.
RoSS.ULTF is an upright ultra-low temperature storage freezer for frozen drug substances in different sizes. The ultra cold storage freezer keeps the desired set point temperature down to -80°C.
BIOMANUFACTURING MEDIA
In this final segment from the Bioprocess Online Live event, “Protecting Bioprocessing Operations and Supply Chains In A Turbulent Economy,” panelists Adam Golin, Jon Lindbloom, and James Sapirstein share their advice and best practices for sourcing suppliers and staying agile during periods of change in the industry.
In this segment from the Bioprocess Online Live event, “Protecting Bioprocessing Operations and Supply Chains In A Turbulent Economy,” panelists share their thoughts on what it means to be resilient and how organizations can embody resilience in their biomanufacturing, which in part requires agility and preparation for the worst-case scenario. The panel was in agreement that earlier-phase companies have the highest opportunity to bake resilience into their operations.
In this segment from the Bioprocess Online Live event, “Protecting Bioprocessing Operations and Supply Chains In A Turbulent Economy,” panelists explain how tariffs imposed by the U.S. are putting competitive pressure on companies to reduce COGs. They also discuss the short- to long-term impact of efforts to onshore biomanufacturing.