1. Kinetic Ligand Binding And 3D Tumor Invasion Technologies To Assess Drug Residence Time And Anti-metastatic Effects

    Metastasis, the spread of cancer cells from the original tumor to secondary locations within the body, is linked to approximately 90% of cancer deaths. The expression of chemokine receptors, such as CXCR4 and CCR7, is tightly correlated with the metastatic properties of breast cancer cells. In vivo, neutralizing the interaction of CXCR4 and its known ligand, SDF1-α (CXCL12), significantly impaired the metastasis of breast cancer cells and cell migration.

  2. Practical pH Measurements

    In this technical note, the various voltage sources within a pH combination electrode are identified, and the contribution of each to the overall pH loop output voltage is reviewed. Sources of deviation of the pH electrode response from the ideal Nernst equation such as zero offsets and asymmetry potentials are presented. Sources of error caused by temperature dependence and acid or alkaline errors at the pH range extremes are also discussed.

  3. TrupH™, 1 Electrode Storage, Cleaning, and Aging

    TrupH measurement systems require proper handling during storage, cleaning, and calibration. Good care of the pH electrode is important, and will optimize the performance of the pH measurement system. Incorrect handling can shorten the life of the electrode, or even result in an unreliable measurement. This application note reviews storage and cleaning procedures for TrupH electrodes. It also explains how TrupH electrodes age, so that the operational lifetime of these electrodes can be maximized. For calibration procedures, please refer to the application note entitled “TrupH Calibration”.

  4. How TrupH Measurement Electrode Interplay With Accurate pH Measurements

    In this technical note, the Nernst equation is reviewed, and various components (measuring electrode, reference electrode, diaphragm, etc) of a TrupH measurement electrode are described. The interplay between these components, as well as their importance to accurate pH measurements, is also presented.

  5. Connecting TrupH™ Measurement System Electrodes To A Transmitter

    TrupH measurement systems require proper handling when connecting the electrode to the transmitter. The quality of the cable and the cleanliness of the connectors can impact the precision and accuracy of the pH measurement loop. This application note specifies requirements for the cable and connector, as well as connection methodology to ensure a proper connection.

  6. Volume Reduction And Process Optimization With Cadence™ Inline Concentrator

    This patented single-pass technology is an opportunity to simplify current TFF processes. It eliminates the conventional TFF recirculation loop and allows product to be concentrated in a single pump pass by utilizing a proprietary flow path and flow ratio control.

  7. Staying On Top Of Microbes: Smarter Testing Technology For Labs Of The Future

    Over the past decade, drug and medical device manufacturers have become leaner and more stream-lined. Given the current market pressures, companies are looking for more ways to improve their bottom-line.

  8. World’s Leading Proofreading Verification And Document Inspection Solution Demo

    We invite you to attend one of our exclusive webinars introducing you to DocuProof the world’s leading proofreading tool for text verification, document inspection and document comparison.

  9. Label-Free Phenotype MicroArrays™ Analysis Of Cellular Energetics And Apoptotic Activity Using Microplate Reading And Phase Contrast Imaging

    Phenotypic screening, or the determination of the effects (phenotypes) that a molecule has on a cell, tissue, or whole organism, dates back to earliest drug discovery efforts.

  10. Quantification Of MMP Activity And Inhibition In A 3D Tumor Invasion Model

    Metastasis, the spread of cancer cells from the primary tumor to secondary locations within the body, is linked to approximately 90% of cancer deaths1. Penetration through the basement membrane is a critical step during the metastatic process, and has been linked to the formation of membrane superstructures called invadopodia2.

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