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  1. Single-Use Bioreactor With Scalable Control Software
    4/1/2015

    This presentation explains how the EMD Serono’s Hyclone Single Use Bioreactor coupled with Finesse’s TrueBioTM software provided a different approach for single-use bioreactor technology and how the two technologies combined performed in a DO probe evaluation for a fed-batch production process.

  2. 21 CFR Part 11 Compliance Software
    4/1/2015

    Title 21 CFR Part 11 is part of the FDA’s Code of Federal Regulations and was put in place so that when records are maintained in an electronic format, they’re still maintained in a manner equivalent to written records. Stringent electronic controls can be put in place to ensure compliance, but procedural controls should also be employed as well. This white paper explains how a specific type of software developed by Finesse can be used to maintain 21 CFP Part 11 compliance as it relates to cell culture and fermentation, both electronically and procedurally.

  3. Seamless Shipping Services Infographic
    4/1/2015

    In global markets, what happens when geography limits access to your logistics partner’s personnel? How can you be confident that every person that touches your high-value product treats it with the care and attention it deserves? Seamless service is just one part of the World Courier way. In our newest infographic, we share what you should know about the differences — and similarities — between shipping agents and owned services.

  4. Application Of The Finesse Glass Bioreactor For Fermentation Of Saccharomyces Cerevisiae
    3/31/2015

    This application note describes the cultivation of Saccharomyces cerevisiae cells in the Finesse glass vessel bioreactor with a maximum working volume of 2.0 L. Using the chemically defined medium D, it was possible to produce up to 5.33 g∙L-1 of dry biomass from 40 g∙L-1 glucose. The cells were grown under aerobic conditions with a specific growth rate up to 0.4 h-1 and a yield coefficient for the biomass of 0.13 g cdw·g gluc-1By Nadezda Perepelitsa, Stephan C. Kaiser and Dieter Eibl

  5. Cultivation Of Sf-9 Insect Cells And rSEAP Expression In The Wave-Mixed Single-Use Finesse SmartRocker Bioreactor
    3/31/2015

    This application note describes the cultivation of Sf-9 suspension cells in the wave-mixed single-use Finesse SmartRocker bioreactor with a maximum working volume of 5 L. Using serum-free, it was possible to produce up to 6.2∙106 cells∙mL-1. The rSEAP expression was induced by the baculovirus expression vector system. Maximum rSEAP activity of up to 58.5 U∙mL-1 was achieved. The results are in the typical range observed in previous cultivations using wave-mixed bioreactor types. By Nadezda Perepelitsa, Stephan C. Kaiser and Dieter Eibl

  6. Cultivation Of Sf-9 Insect Cells And SEAP Expression In The Finesse «SmartGlass» Bioreactor
    3/31/2015

    This application note describes the cultivation of Sf-9 suspension cells in the Finesse «SmartGlass» vessel bioreactor having a maximum working volume of 2.0 L. Using serum-free medium without components of animal origin viable cell densities of up to 4.964∙106 cells∙mL-1 were achieved. The SEAP expression was induced by the baculovirus expression vector system, which provided maximum SEAP activities of 56.4 U∙mL-1. By Stephan C. Kaiser, Ina Dittler, Nina Steiger and Dieter Eibl

  7. Cultivation Of CHO Suspension Cells And SEAP Expression In The Wave-Mixed Single-Use Finesse SmartRocker Bioreactor
    3/31/2015

    This application note describes the cultivation of CHO suspension cells in the wave-mixed single-use Finesse SmartRocker bioreactor with a maximum working volume of 5 L. Using a chemically defined minimal medium, it was possible to produce up to 16.4∙106 cells∙mL-1. SEAP expression was induced by medium exchange and a temperature shift. Maximum SEAP activity of up 33.1 U∙mL-1 was achieved. The results are comparable to cultivations in other wave-mixed bioreactor types. By Nadezda Perepelitsa, Stephan C. Kaiser and Dieter Eibl

  8. Cultivation Of CHO Suspension Cells And SEAP Expression In The Finesse Glass Bioreactor
    3/31/2015

    This application note describes the cultivation of CHO suspension cells in the Finesse glass vessel bioreactor having a maximum working volume of 2.0 L. Using chemically defined minimal media cell densities of up to 7.44∙106 cells∙mL-1 were achieved. The SEAP expression was induced by medium exchange and temperature shift. Maximum SEAP activities of up 63 U∙mL-1 were reached. By Stephan C. Kaiser, Katharina Blaschczok and Dieter Eibl

  9. Mass Propagation Of Nicotiana Tabacum Cv. BY‐2 Suspension Cells In The Finesse Smartrocker Bioreactor
    3/31/2015

    This application note describes the mass propagation of Nicotiana tabacum cv. BY-2 (cultivar tobacco Bright Yellow-2) suspension cells in the Finesse SmartRocker bioreactor at laboratory scale. Maximum fresh cell weights of about 351±9 g•L-1, corresponding to packed cell volumes of 74±2 %, were achieved, which shows the applicability of the Finesse SmartRocker bioreactor to cultivate fast growing plant suspension cells. By Nicole Imseng, Stephan C. Kaiser, Nadezda Perepelitsa, and Dieter Eibl

  10. BPC Chambers Selection Gui
    3/30/2015

    This document helps guide you through the key process of chamber selection based on your application and process requirements.

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