Culture Development White Papers and Case Studies

1. Wireless Dose-Compliance Monitoring In Drug-Delivery Devices 9/28/2015

   Incorporating wireless technology into medical devices is about more than just keeping up with the hottest technology trends; the benefits are real and significant, especially with regard to monitoring and encouraging dose compliance in the pharmaceutical and medical realm. Prior to embarking on the development of a wireless-enabled drug-delivery device, however, it is crucial to know what, specifically, the benefits are, and exactly what kinds of challenges and design considerations must be taken into account.

2. Optimizing Methods In Microtissue Cultivation 4/30/2015

   Cells grown in standard suspension or monolayer culture lose many features that are characteristic of cells in tissues and limit their use to study certain aspects of cell biology.

3. The Client Experience—Key to a CDMO’s Success 5/23/2014

   In the dynamic contract development and manufacturing organization (CDMO) industry, client-focused businesses succeed in retaining and growing our client base by delivering on project objectives and satisfying a client’s expectations.

4. Adaption Of The BioLector Technology To Anaerobic Requirements 5/23/2014

   Biorefineries have reignited interest in anaerobic fermentations with biobutanol production being the principle driver. Already during the First World War Biobutanol and acetone were produced in Clostridium acetobutylicum.

5. Live Cell Imaging Of GPCR Dependent Second-Messenger Systems 4/15/2014

   A significant proportion of academic and drug discovery research is devoted towards the elucidation of second messenger signaling cascades resulting from interactions between G-protein coupled receptors (GPCR) and their ligands. By Paul Held Ph. D. and Peter Banks, Ph. D., BioTek Instruments, Inc. and Paul Tewson, Anne Marie Quinn and Thom Hughes, Montana Molecular

6. A Homogeneous Assay To Quantify Endogenous AKT Phosphorylation In Human Umbilical Vein Endothelial Cells 3/27/2014

   AKT is a serine/threonine protein kinase that plays a key role in cellular processes. AKT has become a popular target for drug discovery campaigns, due to the fact that AKT inhibitors may help to treat a number of cancers.

7. Important Considerations For Implementing A Single-Use Biomanufacturing Strategy 10/18/2013

   Recent trends in biomanufacturing technology and the biopharmaceutical market are supporting the increased adoption of single-use (SU) manufacturing systems. On the demand-side, the biopharma industry is focusing on niche and rare diseases with smaller patient populations, resulting in the need for smaller, more agile biomanufacturing capacity. By Jodi M. Zobrist and Nicole W. O'Brien, Ph. D., Gallus Biopharmaceuticals, LLC

8. Are You Planning To Fail? 9/26/2013

   The problem with managing demand and supply variability in the supply chain stems from the inability of traditional planning systems to solve the bullwhip effect, a problem demonstrated by Prof. By Narayan Laksham and Richard Sherman

9. Automation Of HTRF® elF4E Kinase Assay Using A 3D Tumoroid- Based Cell Model 9/17/2013

   Three-dimensional (3D) cell culture is poised to meet the need for a more in vivo-like cellular model with which to test large and small molecules. This is accomplished by providing a method that allows for the reorganization of cells into a format which re-establishes the necessary cellular architecture and communication networks seen in normal tissue. Recently a methodology has been put forth that incorporates a simplified procedure for the creation of a cell and collagen hydrogel mix. The inclusion of appropriate liquid handling instrumentation can further simplify the process and ensure the generation of accurate, robust results. By Brad Larson, Peter Banks, Nicolas Pierre and Grant Cameron

10. Skip Steps In Cell Culturing 9/14/2013

    With Cell Culture Flask Adapters, the culture can be centrifuged directly in the flask. Data illustrates that cell yield, cell viability, and endpoint analysis results are comparable when cell cultures are processed traditionally or centrifuged directly in the flask using Cell Culture Flask Adapters.