application notes and case studies
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High Yield Protein Production System For Suspension CHO Cells
3/22/2021
Attributes of the new and improved CHOgro High Yield Expression System help researchers obtain gram quantities of protein, simplify workflows, and shorten development pipelines.
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Technical Note: BioSC™ Sequential Multi Column Chromatography
12/23/2008
SMCC uses the same type of stationary phase and the same separation techniques as used in any given batch process. Three of the four columns are available for loading in linear sequence while the fourth column is eluted, regenerated and equilibrated. This happens asynchronously out of sequence with the continuing loading phase until it is ready to return to the linear sequence in its proper turn.
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Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices?
4/29/2022
We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.
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To The Rescue – Getting A Phase I Oncology Study Back On Track
6/21/2013
A small, oncology-focused biotech was experiencing significant data, safety, vendor and monitoring issues in its Phase I programs that were worsening with time.
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A Proactive Approach To Reducing Particulate Risk
A biotech that manufactures injectable large molecules was seeking to evaluate elastomeric components that would help them to attain the highest quality standards for their manufacturing lines.
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Automated Cross Flow Filtration For Process Development, Filter Screening, And Process Optimization At Small Scales
9/13/2007
This application note focuses on microfiltration (pore sizes between 0.1 µm and 1 µm). Microfiltration is ideally suited for separation of cultured cells from the growth medium (broth), as well as for sterilization, and contaminant and particle removal in numerous biopharmaceutical processes
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Liquid Retention Comparison In PC And PETG Containers
5/8/2020
Fluid retention is an important consideration when choosing a container. The physical design and material of construction of the container impact how much fluid remains after dispensing. Fluid retention is an important consideration when choosing which container to use. This application note is a comparison between different container products.
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AAV Thermostability Assessment With Micro-Flow Imaging
11/15/2023
This study demonstrates a micro-flow imaging system's ability to evaluate AAV9 particle purity and stability when subjected to heat stress at two different temperatures: 37°C and 75°C.
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Gentle, Cell-Sensitive Pumping
3/19/2008
Comparison of different peristaltic pump systems for use in animal cell cultures
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Method Development of Ten Antibiotic Compounds Using A Systematic Screening Protocol
9/21/2022
Effective method development of LC and LCMS methods typically involve highly experienced scientists with a wealth of knowledge that has been handed down throughout their organization. For some particularly challenging and complex mixtures this experience may not be enough. Learn how Waters leveraged a generic systematic protocol to separate a variety of APIs in a single run.