'Spider' Assembly For Zeta Plus™ Filter Scale-Up

Four disposable filter configurations are currently available for Zeta Plus filter scale-up study: BC25, BC1000, BC2000, and BCE03. BC1000 and BC2000 are designed for standard Zeta Plus filter testing, and BCE03 for Zeta Plus EXT Series testing. Each configuration’s effective filtration area (EFA), average throughput and estimated hold-up volume are summarized. Another configuration, 47 mm discs, is recommended for standard Zeta Plus filter testing but not for Zeta Plus EXT Series testing. The 47 mm filter discs have to be tested in a reusable metal housing, thus are not completely disposable.

For certain applications, it is useful to have an intermediate scale up device with an EFA between 25 cm² and 650 cm². In this article we introduce a “Spider” assembly design that is capable of accomplishing the following purposes utilizing BC25 capsule filters:

• Provide up to 200 cm² of the effective filtration area to process from 1L to 8L of liquids
• Simultaneously test up to 8 different Zeta Plus grades to select the best performing filter media