Sizing Gold Nanoparticle GNPs For Proper Conjugation

The inertness and biocompatibility of gold nanoparticles GNPs makes them very useful for specific applications such as medical imaging, drug delivery, gene delivery, scaffold directed assembly and molecular sensing, where the size of GNPs is important. There is a need to measure the size of GNPs to make sure there is proper conjugation without aggregation.

The antibody conjugated GNPs are used as potential molecular probes in various light based imaging techniques such as diffuse optical tomography, photoacoustic imaging, optical coherence tomography, etc. The conjugation of the proteins to GNPs is mainly due to the electrostatic interactions between the proteinGNP complexes. Particle aggregation prevents the use of GNPs in the afore mentioned applications. Thus, there is a need to measure the size of GNPs to make sure there is proper conjugation without aggregation.