White Paper: Economic Analysis Of Single-Use Tangential Flow Filtration For Biopharmaceutical Applications

By Michael LaBreck, Mark Perreault, Novasep

Prior to creating an accurate economic model for TFF, a thorough understanding of the process where the TFF is used is needed. A process model is a valuable tool when properly executed and it must accurately include all critical aspects of the purification process. Considerations of labor, utilities, consumables, and waste contribute to the complexity of an accurate process model. All aspects of the process must combine into a robust operation that easily scales up to a commercial manufacturing process. Often single-use technologies must be weighed against traditional re-usable process steps during this planning phase.

When creating a process model, the various process steps may be graphically depicted in a process flow diagram as shown in figure1. Once the diagram has been created, the details of each step are considered and an economic model may be generated.