Magazine Article: Innovation In Alternative Chromatography By Eric Langer, president and managing partner, BioPlan Associates, Inc.
For years, many biopharma industry manufacturers have said the use of Protein A chromatography for purifying biologics (a mainstay process) isn't broken, so why fix it? However, Protein A media remains a major thorn in the side of operators due to its high cost, as well as the cost of recycling and cleaning/validation. Alternative technologies for purification of antibodies have been and are being developed with longer lifetimes and therefore, lower cost-per-unit of protein produced.
Article: Efficient and Cost-Effective Removal Of Residual Endotoxin By Ben Galarza, Jason Shipp, Buzz Lobbezoo, Jennie Walden and Steve Burton, ProMetic BioSciences Ltd
Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell culture expression systems such as E. coli.
White Paper: Effect Of Sterilization On Mechanical Properties Of Silicone Rubbers By Emilie Gautriaud, Keith T. Stafford, Jennifer Adamchuk, Mark W. Simon and Duan Li Ou, Saint-Gobain, Northboro R&D Center
Silicone rubber is widely used in the pharmaceutical industry where sterilizability is an essential requirement for all fluid transfer equipment. Pharmaceutical products must be sterilized frequently and repeatedly by high level energy and/or chemical vapor in order to eliminate bacterial surface contamination.
Gain the insight and contacts you need to make your single-use platforms more efficient, economical, and meet more complex drug demands at IBC's 11th Single-Use Applications for Biopharmaceutical Manufacturing conference, taking place June 9 and 10, 2014, in Boston, MA.
Bioresearch Online readers can save 20 percent off the standard rate with priority code B14187BIO20 during online registration at http://bit.ly/1jHaZ86.
Selecting the right fluid-handling components for your device is critical. Parts that are unreliable or do not perform as promised can alter instrument performance, delay market release, greatly increase field service costs, and jeopardize the relationship with your customer.
AseptiQuik STC Connectors integrate the AseptiQuik sterile connector and the Steam-Thru II SIP connector, giving manufacturers even greater flexibility for hybrid stainless steel and single-use processing.
As the biologics market continues to grow, with additional launches, expanding indications, and approvals of biosimilars, the delivery platform will play a more critical role in product differentiation.