Highly Potent, Cell-Permeable And Selective Inhibitor

Y-27632 is a highly potent, cell-permeable and selective inhibitor of ROCK. As well as modulating smooth-muscle contraction by inhibiting Ca2+ sensitization, Rho/ROCK pathway may help to regulate integrin-mediated cell adhesion and motility. Furthermore, it inhibits cell death at cell dispersion of human ES cell and human iPS cells. When cryopreserved human ES cells and human iPS cells were thawed and cultured in the medium including Y-27632 the colony forming activity was confirmed to be improved.