Application Note

Protecting HPLC Columns From Particulate Contamination Using Column Inlet Filters

Source: IDEX

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Technical Note: Protecting HPLC Columns From Particulate Contamination Using Column Inlet Filters

A column inlet filter removes particles from the mobile phase before they reach the guard column and analytical column. It must have a filtering capacity large enough to prevent back pressure buildup, yet a volume small enough to prevent excessive sample dispersion (loss of resolution). Rheodyne has two filter geometries that meet these conflicting requirements. The two designs allow the filter and column to be matched, providing good capacity without unnecessary loss of resolution. This article describes these filters, tells which one to select for various applications, and shows conditions under which they will cause a loss of resolution.

Click Here To Download:
Technical Note: Protecting HPLC Columns From Particulate Contamination Using Column Inlet Filters

SOURCE: IDEX